Micky van de Ven Double Ends Everton's Run at New Home Ground
Micky van de Ven became the first defender to score twice in a English top-flight match for Tottenham since the Belgian defender in March 2013.
Key points
The Spurs defender nods into the net two times in first half
The home side's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr scores final goal in 89th minute
The defeat is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored twice as Spurs prolonged their winning streak on the road in the Premier League and delivered Everton their initial loss at their new home.
Everton were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman struck on two occasions from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a third to put the game to bed.
Jake O'Brien thought he had levelled the scores a short while after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a number of chances, while the Italian goalkeeper made a series of excellent saves to guarantee the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee stepped in, advising Craig Pawson to review the score on the pitchside monitor and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win elevates the manager's side up to third in the Premier League, a handful of points off local foes and table-toppers Arsenal.
Everton stay in 14th position and sit six points ahead of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at each end of the field
Following a drab weekday performance in the European competition against Monaco, where they mustered a mere two shots on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was failed to make much of an impact before being replaced for Richarlison after an hour on the field, but it emerged he wasn't needed in the final outcome.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an free Van de Ven to score.
And the captain - stepping up as skipper in the Argentine's unavailability - added his next goal in added time as he outjumped the England keeper to nod in.
Van de Ven was just as outstanding in defensive duties, partnering effectively with Kevin Danso as the pair dealt excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Everton missing striker's instinct
Everton's recent stadium had been a happy hunting ground, but it appears the novelty may have faded somewhat and supporters headed to the exits after Sarr's third for Spurs.
The end in Everton's winning streak at home won't be a massive concern for David Moyes, but their striker situation are.
The forward and Thierno Barry - the Toffees' pair of recognised centre-forwards - had scored only a single goal combined before the weekend's match.
And they were failed to add to that miserable record on a wet and gloomy night on in Liverpool.
The striker's performance was summed up when he opted to overhead kick a clear chance from near the goal, despite having space and time to readjust for a simpler shot that would have challenged the keeper.
Barry, as well, failed to make an impact after coming on for the starter in the second half.
It was not for a lack of opportunity. Most of Everton's offensive moves came through the winger and Ndiaye, who relentlessly whipped threatening balls into the Tottenham box.
Upcoming fixtures for these two sides?
The Toffees: The team head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against the Magpies.